Dementia with Lewy Bodies. A Distinct Non‐Alzheimer Dementia Syndrome?
Identifieur interne : 001F12 ( Main/Exploration ); précédent : 001F11; suivant : 001F13Dementia with Lewy Bodies. A Distinct Non‐Alzheimer Dementia Syndrome?
Auteurs : Paul G. Ince ; Elaine K. Perry ; Chris. M. MorrisSource :
- Brain Pathology [ 1015-6305 ] ; 1998-04.
Abstract
Lewy body formation is central to the pathological phenotype of a spectrum of disorders. The most familiar of these is the extrapyramidal syndrome of idiopathic Lewy‐body Parkinson's disease (PD). Studies of dementia in the elderly suggest that another manifestation of Lewy body pathology is equally or more common than Parkinson's disease. This syndrome of Dementia with Lewy bodies (DLB) has been given a number of diagnostic labels and is characterised by dementia, relatively mild parkinsonism, visual hallucinations, and fluctuations in conscious level. Although many of these features can arise in Parkinson's disease, the patients with DLB tend to have early neuropsychiatric features which predominate the clinical picture, and the diagnosis of the syndrome in practice is more concerned with the differential diagnosis of Alzheimer's disease (AD). Distinction from AD has clinical importance because of potentially differing therapeutic implications. Diagnostic guidelines for the clinical diagnosis and pathological evaluation of DLB are reviewed. Research into the disorder has centered around characterising the clinical, neuropsychological, pathological, neurochemical and genetic relationships with Alzheimer's disease on the one hand, and Parkinson's disease on the other. Many cases of DLB have prominent pathological features of AD and there are some shared genetic risk factors. Differences from the pathology of PD are predominantly quantitative rather than qualitative and evidence is discussed which suggests that DLB represents a clinicopathological syndrome within the spectrum of Lewy body disorders. The possibility that the syndrome represents a chance association of PD and AD is not supported by published studies.
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DOI: 10.1111/j.1750-3639.1998.tb00156.x
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Ince</name><affiliation><wicri:noCountry code="subField">University of Newcastle upon Tyne</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField">Newcastle upon Tyne</wicri:noCountry></affiliation></author><author><name sortKey="Perry, Elaine K" sort="Perry, Elaine K" uniqKey="Perry E" first="Elaine K." last="Perry">Elaine K. Perry</name><affiliation><wicri:noCountry code="subField">University of Newcastle upon Tyne</wicri:noCountry></affiliation></author><author><name sortKey="Morris, Chris M" sort="Morris, Chris M" uniqKey="Morris C" first="Chris. M." last="Morris">Chris. M. Morris</name><affiliation><wicri:noCountry code="subField">University of Newcastle upon Tyne</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Pathology</title><idno type="ISSN">1015-6305</idno><idno type="eISSN">1750-3639</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1998-04">1998-04</date><biblScope unit="volume">8</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="299">299</biblScope><biblScope unit="page" to="324">324</biblScope></imprint><idno type="ISSN">1015-6305</idno></series><idno type="istex">04F779A12F3855D96CA9C608E06416273447DE81</idno><idno type="DOI">10.1111/j.1750-3639.1998.tb00156.x</idno><idno type="ArticleID">BPA299</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1015-6305</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lewy body formation is central to the pathological phenotype of a spectrum of disorders. The most familiar of these is the extrapyramidal syndrome of idiopathic Lewy‐body Parkinson's disease (PD). Studies of dementia in the elderly suggest that another manifestation of Lewy body pathology is equally or more common than Parkinson's disease. This syndrome of Dementia with Lewy bodies (DLB) has been given a number of diagnostic labels and is characterised by dementia, relatively mild parkinsonism, visual hallucinations, and fluctuations in conscious level. Although many of these features can arise in Parkinson's disease, the patients with DLB tend to have early neuropsychiatric features which predominate the clinical picture, and the diagnosis of the syndrome in practice is more concerned with the differential diagnosis of Alzheimer's disease (AD). Distinction from AD has clinical importance because of potentially differing therapeutic implications. Diagnostic guidelines for the clinical diagnosis and pathological evaluation of DLB are reviewed. Research into the disorder has centered around characterising the clinical, neuropsychological, pathological, neurochemical and genetic relationships with Alzheimer's disease on the one hand, and Parkinson's disease on the other. Many cases of DLB have prominent pathological features of AD and there are some shared genetic risk factors. Differences from the pathology of PD are predominantly quantitative rather than qualitative and evidence is discussed which suggests that DLB represents a clinicopathological syndrome within the spectrum of Lewy body disorders. The possibility that the syndrome represents a chance association of PD and AD is not supported by published studies.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ince, Paul G" sort="Ince, Paul G" uniqKey="Ince P" first="Paul G." last="Ince">Paul G. Ince</name><name sortKey="Morris, Chris M" sort="Morris, Chris M" uniqKey="Morris C" first="Chris. M." last="Morris">Chris. M. Morris</name><name sortKey="Perry, Elaine K" sort="Perry, Elaine K" uniqKey="Perry E" first="Elaine K." last="Perry">Elaine K. Perry</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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